Biomechanics

In functional adaptation by tissue remodeling and regeneration, the mechanism by which local mechanical cue is sensed by cells and tissues remodel their structure to meet functional demands remains unclear because of the complex hierarchical system in spatiotemporal scales. To better understand the mechanoregulation of tissue adaptation by remodeling and regeneration, bridging spatial and temporal scales from microscopic molecular and cellular activities to macroscopic tissue behaviors is very important. Based on multiscale system biomechanics, our department is involved in integrated researches of modeling and simulation combined with experiments, focusing on mechano-biochemical couplings in the dynamics of structure-function relationships in tissues and cells.

Academic Staff

* Add ".kyoto-u.ac.jp" to each E-mail address.

Taiji ADACHI

Professor (Institute for Frontier Medical Sciences)

Researches

Taiji ADACHIProf. Adachi's research activities have been focused on the functional adaptation by remodeling/reorganization in living systems those have mechanical hierarchy in structure-function relationships from the macroscopic organ/tissue levels to the microscopic cell/molecular levels. To clarify their mechanoregulation, he has been conducting integrated researches of modeling and simulation combined with experiments by bridging spatiotemporal scales from molecular and cellular activities to tissue behaviors.

Contacts

Rm#415, East Bldg, Institute for Frontier Medical Sciences, Yoshida Campus
TEL: +81-75-751-4853
FAX: +81-75-751-4853
E-mail: adachi@frontier

Yasuhiro INOUE

Yasuhiro INOUEAssociate Professor (Institute for Frontier Medical Sciences)

Researches

Mathematics and biophysics of self-organizing life-like dynamics, Meta-model on dynamics with hyper degrees of freedom.

Contacts

Rm#404A, East Bldg, Institute for Frontier Medical Sciences, Yoshida campus
TEL: +81-75-751-4125
E-mail: inoue@frontier

Yoshitaka KAMEO

Yoshitaka KAMEOAssistant Professor (Institute for Frontier Medical Sciences)

Researches

He has been working on the biomechanics of functional adaptation of living tissues to the changes in mechanical environment.

Contacts

Rm#415, East Bldg, Institute for Frontier Medical Sciences, Yoshida Campus
TEL: +81-75-751-4854
FAX: +81-75-751-4854
E-mail: kameo@frontier

Research Topics

  1. Biomechanics and mechanobiology of nano- and microscale structures in living systems.
  2. Understanding mechanisms of bone functional adaptation by remodeling and regeneration.
  3. Multiscale modeling and simulation of actin filament dynamics in cell migration.
  4. Elucidation of mechano-biochemical coupling mechanisms in mechanosensory cells.
  5. Nano- and microengineering of artificial systems combined with biomolecular and cellular systems.

adachi research 1

Fig. 1: Mechanical hierarchy in bone functional adaptation by remodeling and regeneration

adachi research 2

Fig.2: Multiscale dynamics of filamentous actin cytoskeleton in cell migration