Biomechanics

In functional adaptation by tissue remodeling and regeneration, the mechanism by which local mechanical cue is sensed by cells and tissues remodel their structure to meet functional demands remains unclear because of the complex hierarchical system in spatiotemporal scales. To better understand the mechanoregulation of tissue adaptation by remodeling and regeneration, bridging spatial and temporal scales from microscopic molecular and cellular activities to macroscopic tissue behaviors is very important. Based on multiscale system biomechanics, our department is involved in integrated researches of modeling and simulation combined with experiments, focusing on mechano-biochemical couplings in the dynamics of structure-function relationships in tissues and cells.

Academic Staff

* Add ".kyoto-u.ac.jp" to each E-mail address.

Taiji ADACHI

Professor (Institute for Frontier Life and Medical Sciences)

Researches

Taiji ADACHIProf. Adachi's research activities have been focused on the functional adaptation by remodeling/reorganization in living systems those have mechanical hierarchy in structure-function relationships from the macroscopic organ/tissue levels to the microscopic cell/molecular levels. To clarify their mechanoregulation, he has been conducting integrated researches of modeling and simulation combined with experiments by bridging spatiotemporal scales from molecular and cellular activities to tissue behaviors.

Contacts

Rm#327, Molecular Biology Research Bldg  Institute for Frontier Life and Medical Sciences, University hospital west campus
TEL: +81-75-751-4853
FAX: +81-75-751-4853
E-mail: adachi@infront

OKEYO, Kennedy Omondi

Junior Associate Professor (Institute for Frontier Life and Medical Sciences)OKEYO, Kennedy Omondi

Researches

On-going research is focused on elucidating the mechanisms of self-organization and differentiation of stem cells by modulating the  cell culture microenvironment  using microfabricated tools. 
Also, we are developing organ-on-a-chip models of the lung alveolar, blood-brain-barrier etc for application to drug screening and/or clarifying the mechanisms of diseases associated with these organs. 

Contacts

Rm#323, Molecular Biology Research Bldg  Institute for Frontier Life and Medical Sciences, University hospital west campus
TEL: +81-75-751-4119
FAX: +81-75-751-4119
E-mail: okeyo@infront

Yoshitaka KAMEO

Yoshitaka KAMEOAssistant Professor (Institute for Frontier Life and Medical Sciences)

Researches

He has been working on the biomechanics of functional adaptation of living tissues to the changes in mechanical environment.

Contacts

Rm#113, Molecular Biology Research Bldg  Institute for Frontier Life and Medical Sciences, University hospital west campus
TEL: +81-75-751-4854
FAX: +81-75-751-4854
E-mail: kameo@infront

Koichiro MAKI

maki.jpgAssistant Professor (Institute for Frontier Life and Medical Sciences)

Researches

His research has been focused on biomechanical mechanisms of molecular and cellular mechanoadaptation utilizing single-molecular force spectroscopy and real-time imaging.

Contacts

Rm#327, Molecular Biology Research Bldg  Institute for Frontier Life and Medical Sciences, University hospital west campus
TEL: +81-75-751-4854
FAX: +81-75-751-4854
E-mail: maki@infront

Research Topics

  1. Elucidation of intrinsic regulatory mechanisms of differentiation, tissue/organ formation and growth by stem cells
  2. Clarification of functional adaptation mechanism of bone remodeling and regeneration
  3. Elucidation of time-space coupling mechanism in the temporal control of brain development
  4. Understanding mechanochemical coupling mechanism in cellular mechanosensing and adhesion control
  5. Synthesis of cell system functionality by microengineering-based control of cell adhesion microenvironment

バイオメカニクスFig.120190406追加

Fig. 1: Bone can remodel its outer shape and inner structure to adapt to the surrounding mechanical environment. This study aims to clarify the mechanism of bone functional adaptation achieved  by cooperative cellular activities.

バイオメカニクスFig.220190406追加

Fig.2: Morphogenesis of biological tissues is regulated by mechanical forces generated through multicellular interactions. This study aims to clarify the mechanism of tissue morphogenesis using experiments and simulations.