Biomechanics and Nano-Bioengineering for Living Tissue, Cells, and Biomolecules

The Laboratory of Biomechanics aims to clarify the self-organized regulatory mechanisms of diverse biological phenomena through interdisciplinary approaches encompassing mechanics, life science, and medical science. Our research topics cover developmental processes (cell differentiation, morphogenesis, and growth) as well as tissue/organ remodeling and regeneration which underlie functional adaptation to the environment. A major focus of our research is to understand how well-organized dynamics of living systems emerges from complex molecular and cellular interactions. To this end, we are integrating biomechanics and mechanobiology approaches to highlight the roles of “adaptation to mechanical environment” and “hierarchy of structure and function” in the living organisms using mathematical modeling, simulation and experiments.

Academic Staff

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Professor (Institute for Life and Medical Sciences)

Research Interests

Taiji ADACHIProf. Adachi's research activities have been focused on the functional adaptation by remodeling/reorganization in living systems those have mechanical hierarchy in structure-function relationships from the macroscopic organ/tissue levels to the microscopic cell/molecular levels. To clarify their mechanoregulation, he has been conducting integrated researches of modeling and simulation combined with experiments by bridging spatiotemporal scales from molecular and cellular activities to tissue behaviors.


Rm#208, 1st Bldg, Institute for Life and Medical Sciences, University hospital west campus
TEL: +81-75-751-4853
FAX: +81-75-751-4853
E-mail: adachi@infront

Koichiro MAKI

maki.jpgAssistant Professor (Institute for Life and Medical Sciences)

Research Interests

His research has been focused on biomechanical mechanisms of molecular and cellular mechanoadaptation utilizing single-molecular force spectroscopy and real-time imaging.


Rm#210, 1st Bldg, Institute for Life and Medical Sciences, University hospital west campus
TEL: +81-75-751-4854
FAX: +81-75-751-4854
E-mail: maki@infront

Research Topics

  1. Functional adaptation mechanisms of bone to mechanical environment
  2. Continuum mechanics-based modeling for multi-layered brain formation
  3. Mechano-biochemical coupling mechanisms in osteocytic mechanotransduction
  4. In silico and in vitro modeling of multicelluar tissue morphogenesis
  5. DNA transcription mechanisms regulated by nano-scale chromatin dynamics


Fig. 1:Bone can remodel its outer shape and inner structure to adapt to the surrounding mechanical environment. This study aims to clarify the mechanism of bone functional adaptation achieved through cooperative cellular activities.


Fig.2: Morphogenesis of biological tissues is orchestrated by mechanical forces at the multiscale. By combining experiments and simulations, this study aims to clarify the mechanisms of tissue morphogenesis.